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In one study, the yeast Saccharomyces boulardii resulted in fewer recurrences in a group of patients with RCDI (35 vs. 65) (105); however, the study had inadequate randomization by the type of adjunct CDI antibiotic. A small trial of Lactobacillus plantarum 299v combined with metronidazole had recurrence rates of 35 compared with 66 in the control groups, a difference that was not statistically significant (106).
Two small RCTs of Lactobacillus rhamnosus GG failed to show efficacy in treating RCDI (107,108).