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After oral administration of MBZ-OS, the drug concentrations in lung, spleen kidney, heart and brain were higher than that of the MBZ-1 tragacanth. However, contributed by the accumulated indissolvable parent drug, the C max value of MBZ-1 tragacanth was nearly 6 times of the new formulation in the intestine. On the other hand, MBZ-OS promoted more MBZ into the systemic circulation. It was found that the C max and AUC 0-t values of MBZ-OS in liver and kidney were not changed as much as in plasma.